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Document Details :

Title: Diarree van vreemde origine
Journal: Tijdschrift voor Geneeskunde
Volume: 70    Issue: 4   Date: 2014   
Pages: 193-195
DOI: 10.2143/TVG.70.04.2001556

Abstract :
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Diarrhoea of a remarkable origin
The medical history of a 51-year-old woman with diarrhoea after travelling to South-Africa is discussed. She presented with abdominal discomfort with an abnormal stool production, changing from constipation to watery diarrhoea and back. During the observation, she initially developed bloody diarrhoea and fever, though under a symptomatic therapy the complaints disappeared after five days.
After a thorough investigation, the diagnosis of a stage IV mantle cell lymphoma (MCL) was made based on the results of a colon biopsy. An MCL is a rare subgroup of the Non-Hodgkin lymphomas with the chromosomal t(11:14) translocation as the molecular hallmark, resulting in the overexpression of cyclin D1, which is detectable by immunohistochemistry on the biopsy. The diagnosis is made upon a biopsy of the involved organs. The most common extranodular involvement is the gastrointestinal tractus. After standard chemotherapy followed by stem cell transplantation, no evidence of residual disease occurred.

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