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Document Details :
Title: Remote ischaemic preconditioning reduces myocardial ischaemic reperfusion injury in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention
Author(s): Z. Liu , L. Zhao , D. Hong , J. Gao
Journal: Acta Cardiologica
Volume: 71 Issue: 5 Date: 2016
Background: Myocardial ischaemic reperfusion injury (IRI) increases infarct size and results in poor prognosis in ST-segment-elevation myocardial infarction (STEMI).
Objectives: The present study aims to determine whether remote ischaemic preconditioning (RIPC) alleviates myocardial IRI in STEMI patients undergoing primary percutaneous coronary intervention (PPCI).
Methods: One hundred and nineteen STEMI patients were randomly assigned to the PPCI group (patients receiving only PPCI) (n = 60) and R + PPCI group (patients receiving RIPC and PPCI) (n = 59). The primary study end point was early microvascular obstruction measured by cardiovascular magnetic resonance in all patients.
Results: RIPC improved the percentage of myocardial blush grade (2-3) (P = 0.035) and left ventricular ejection fraction (P = 0.039) in the R + PPCI group. Importantly, RIPC reduced early MO (MO, P = 0.011; MO%LV, P = 0.016) and infarct size (%LV, P = 0.042) in the R + PPCI group compared to the PPCI group.
Conclusions: The present study showed that RIPC before stenting alleviated myocardial IRI and reduced infarct size in patients with STEMI.