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Document Details :

Title: Haemoglobin A1c as a marker predicting extent and severity of coronary artery disease in non-diabetic patients
Author(s): A. Farrag , W. Ammar , A.E.A. Hady , N.E. Samhoon
Journal: Acta Cardiologica
Volume: 71    Issue: 5   Date: 2016   
Pages: 581-585
DOI: 10.2143/AC.71.5.3167502

Abstract :
Objective: Lowering haemoglobin A1c (HbA1c) was shown to be associated with reduction of microvascular, neuropathic and possibly macrovascular complications in diabetic patients. However, in non-diabetic patients, few reports have examined the relation between HbA1c and extent of coronary artery disease. The aim of this study was to examine the relationship between HbA1c level and severity of coronary artery disease (CAD) in non-diabetic patients scheduled for elective coronary angiography.
Methods: We prospectively studied 408 consecutive non-diabetic patients with or without history of previous myocardial infarction who were scheduled for conventional coronary angiography. HbA1c was measured in all patients at the time of admission. Severity of CAD was assessed by the Gensini score. Gensini score > 30 was considered severe coronary atherosclerosis. Patients were divided into two groups: the high-risk group (HbA1c, 5.7-6.4%) and the low-risk group (HbA1c, < 5.7%).
Results: Patients in the high-risk group had a higher Gensini score (45.1 ± 36.7 vs 26.8 ± 26.0, P < 0.001). Patients with a Gensini score > 30 had higher values of HbA1c (6.0 ± 0.48 vs 5.75 ± 0.54, P < 0.001). HbA1c showed a positive correlation with the Gensini score. HbA1c value of 5.85% showed a sensitivity and specificity of 70 and 50%, respectively, for prediction of severe coronary atherosclerosis.
Conclusion: HbA1c is significantly associated with severe coronary atherosclerosis in non-diabetic patients.

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