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Document Details : Title: CPAP therapy reduces blood pressure for patients with obstructive sleep apnoea: an update meta-analysis of randomized clinical trials Author(s): Y. Sun , Z.-Y. Huang , Q.-R. Sun , L.-P. Qiu , T.-T. Zhou , G.-H. Zhou Journal: Acta Cardiologica Volume: 71 Issue: 3 Date: 2016 Pages: 275-280 DOI: 10.2143/AC.71.3.3152087 Abstract : Objective: Studies suggest that continuous positive airway pressure (CPAP) therapy may decrease blood pressure for patients with obstructive sleep apnoea (OSA). However, these benefits are not completely clear. Method: We undertook a meta-analysis of randomized trials identified in systematic researches of MEDLINE, EMBASE, and the Cochrane Database. Results: Twelve studies (1,720 patients) were included. Overall, CPAP therapy significantly decreased 24-h systolic blood pressure (SBP) (MD, -2.03; 95% CI, -3.64 to -0.42; P = 0.01; I2 = 0%) and 24-h diastolic blood pressure (DBP) (MD, -1.79; 95% CI, -2.89 to -0.68; P = 0.001; I2 = 0%) compared with the control group. Meanwhile, CPAP was associated with significantly lower daytime DBP (MD, -1.43; 95% CI, -2.67 to -0.19; P = 0.02; I2 = 0%), nighttime SBP (MD, -3.94; 95% CI, -5.85 to -2.04; P < 0.0001; I2 = 34%), nighttime DBP (MD, -1.64; 95% CI, -2.88 to -0.40; P = 0.009; I2 = 0%), clinic SBP (MD, -4.53; 95% CI, -6.07 to -2.99; P < 0.00001; I2 = 70%) and clinic DBP (MD, -2.94; 95% CI, -4.16 to -1.72; P < 0.00001; I2 = 56%). Furthermore, the risk of cardiovascular events was significantly decreased in the CPAP group (OR, 0.59; 95% CI, 0.36 to 0.98; P = 0.04; I2 = 0%). Conclusions: CPAP therapy was associated with a significantly decreased level of BP and cardiovascular events. However, larger randomized studies are needed to confirm these findings. |
