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Document Details :

Title: Een man met oedeem van de onderste ledematen
Author(s): VAN DEN BULCK H, BLOCKMANS D
Journal: Tijdschrift voor Geneeskunde
Volume: 60    Issue: 10   Date: 2004   
Pages: 700-703
DOI: 10.2143/TVG.60.10.5001871

Abstract :
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A man with oedema of both legs
Retroperitoneal fibrosis (RPF) is an uncommon disorder, characterised by a chronic non-specific inflammation and fibrosis of the retroperitoneum which can encase and obstruct retroperitoneal structures.
In the majority of cases, the cause is unknown. About one third is due to malignancy, haemorrhage, surgery, infection, aortitis or medication. In our patient, the use of pergolide probably caused RPF.
Most cases of non-malignant RPF will respond to medical treatment with steroids. Alternative treatment regimens (i.e. intensive immunosuppression and tamoxifen) are indicated for steroid-resistant cases. Surgical treatment by surgical ureterolysis or stenting is indicated if renal excretion is impaired.

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