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Document Details :
Title: Een 53-jarige patiënte in acute respiratoire distress
Author(s): GHIJSELS E, RAPPOORT L
Journal: Tijdschrift voor Geneeskunde
Volume: 59 Issue: 14-15 Date: 2003
Hydrochlorothiazide-induced noncardiogenic pulmonary edema
Noncardiogenic pulmonary edema is caused by leakage of plasma into the pulmonary interstitial space, due to an increased permeability of the capillary wall (and not to a raised hydrostatic pressure). The pathophysiological mechanism of hydrochlorothiazide-induced pulmonary edema remains unclear, but is supposed to be idiosyncratic. The therapy is supportive. The overall prognosis is good: symptoms usually resolve within twenty-four hours, though fatal cases have been described. Avoidance of reexposure to the causative drug is mandatory.