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Document Details : Title: A Mathematical model of Alzheimer's Disease and the Apie Gene Author(s): MACDONALD, A. , PRITCHARD, D. Journal: ASTIN Bulletin Volume: 30 Issue: 1 Date: May 2000 Pages: 69-110 DOI: 10.2143/AST.30.1.504627 Abstract : Alzheimer's disease (AD) accounts for a significant proportion of long-term care costs. The recent discovery that the e4 allele of the ApoE gene indicates a predisposition to earlier onset of AD raises questions about the potential for adverse selection in long-term care insurance, about long-term care costs in general, and about the potential effects on costs of gene therapy, or better targetted treatments for AD. This paper describes a simple Markov model for AD, and the estinaation of the transition intensities from the medical and epidemiological literature. |
