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Document Details :
Title: Adipose tissue volume differences around the heart between subjects without coronary atherosclerosis and coronary heart disease patients
Author(s): J. Wu , X. Zhang , X. Li , L. Yang
Journal: Acta Cardiologica
Volume: 71 Issue: 3 Date: 2016
Objectives: Preliminary research indicates that epicardial (EAT) and intrathoracic adipose tissues (IAT) may associate with coronary atherosclerosis. Therefore, we investigated differences in adipose tissue (AT) volume around the heart between subjects without coronary atherosclerosis (CAS) and coronary heart disease (CHD) patients.
Methods and results: 102 consecutive subjects without coronary atherosclerosis and 102 coronary heart disease patients identified by coronary-artery computed tomography (CT) angiography (CCTA) were recruited. Through the use of a dual-source CT scanner, the volumes of adipose tissue around the heart were measured using axial data. The volume differences of EAT, IAT, and pericardial adipose tissue (PAT) between subjects without CAS and CHD patients were analysed. Without accounting for sex differences, CHD patients had higher mean EAT volume. In males, there was no difference of AT volume between subjects without CAS and CHD patients. In females, EAT and IAT volumes were statistically different between the two groups. Additionally, significant differences of EAT/IAT ratios were found in both sexes.
Conclusions: Generally, CHD patients exhibit greater EAT volume than subjects without CAS. However, when sex differences are considered, our findings suggest that, in males, increased EAT/IAT ratio is related to CHD, while in females, increased volumes of EAT, IAT, as well as increased EAT/IAT ratio are related to CHD.