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Document Details :

Title: Clinical benefit of atrio-ventricular delay optimization in patients with a dual-chamber pacemaker: a pilot study
Subtitle: The CBRAVO trial (NCT01998256)
Author(s): T. Cools , T. Daerden , L. Herbots , R. Geukens , J. Verwerft , P. Koopman , D. Dilling-Boer , D. Hansen , P. Vranckx , P. Dendale
Journal: Acta Cardiologica
Volume: 71    Issue: 3   Date: 2016   
Pages: 257-265
DOI: 10.2143/AC.71.3.3152085

Abstract :
Objective: Outcome data on exercise capacity following atrio-ventricular (AV) optimization of dual-chamber pacing are sparse. Pacemaker settings are often left at manufacturers’ nominal values upon implantation. We studied the short-term effect of AV optimization on exercise capacity in patients with a dual-chamber pacemaker.
Methods and results: Twenty-eight patients (mean age 73 ± 14 y) with a dual-chamber pacemaker, were randomized towards either nominal AV settings (group 1) or echo-guided AV optimization using the iterative mitral inflow VTI (velocity time integral) method (group 2) at baseline. At 4 weeks, patients were crossed-over to AV optimization in group 1 and returned to nominal AV settings in group 2 for another period of 4 weeks. Oxygen uptake efficiency slope improved significantly after AV optimization (by 126.7 mL/logL ± 190.7 mL/logL; P = 0.003).
Conclusions: AV optimization in dual-chamber pacing significantly improved functional capacity after 4 weeks. These data provide the background for further validation studies.

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