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Document Details : Title: Anti-platelet effects of nimesulide in isoproterenol-induced myocardial ischaemia and infarction in rabbits Author(s): S. Ahmed , S. Gul , H. Ze Jaafar , M. Moga , M. Zia-Ul-Haq , L. Dima Journal: Acta Cardiologica Volume: 70 Issue: 4 Date: 2015 Pages: 401-408 DOI: 10.2143/AC.70.4.3094648 Abstract : Background: The present study was designed to determine the effects of cyclooxygenase-2 (COX-2) inhibitor-nimesulide on platelet activating factor (PAF) and arachidonic acid (AA)-induced platelet aggregation during myocardial infarction (MI) and ischaemia in rabbits. Methods: Rabbits were divided into three groups; group I served as control and contains normal rabbits that received saline, group II rabbits received saline before induction of MI, and group III rabbits received nimesulide (25 mg/kg) before MI induction. Myocardial infarction was induced by isoproterenol (ISP) (65 mg/kg) and confirmed by biochemical, electrophysiological and histopathological methods. Platelet aggregation was induced with arachidonic acid (AA) and platelet activating factor (PAF), and monitored by using light transmission aggregometery. Results: When platelets were challenged with two different aggregating agents, nimesulide-treated infarcted rabbits showed resistance to platelet aggregation while non-treated infarcted rabbits were found prone to aggregation with both aggregating agents (P < 0.05). Conclusion: These results suggest platelet inhibitory effects of nimesulide during experimental ischaemia and infarction in rabbits. |
