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Document Details : Title: Does brucellosis cause arterial stiffness and ventricular remodelling through inflammation? Author(s): T. Togan , O. Ciftci , M. Gunday , H. Narci , H. Arslan Journal: Acta Cardiologica Volume: 70 Issue: 2 Date: 2015 Pages: 185-195 DOI: 10.2143/AC.70.2.3073510 Abstract : Background: Like other acute and chronic infections, Brucella infection leads to endothelial dysfunction. Furthermore, it has been suggested that the chronic inflammatory state present in chronic infectious diseases leads to an acceleration in atherosclerosis. For the prediction of CAD, it is possible to use epicardial fat thickness (EFT) as an adjunctive marker beside the classical risk factors, as it is easily and non-invasively evaluated by transthoracic echocardiography. The purpose of this study was to investigate the presence of impaired myocardial performance as well as of increased arterial stiffness and EFT in patients who had been infected with brucellosis in the past. Methods: Included in the study were twenty-seven brucellosis patients and twenty-six healthy volunteers. Using EFT and transthoracic echocardiography, which included Doppler echocardiography in combination with tissue Doppler imaging (TDI), all the patients were examined to measure their aortic stiffness index (AoSI), aortic distensibility (AoD), and aortic elastic modulus (AoEM) values. Results: A statistically significant increase was observed in hs-CRP, aortic stiffness index, aortic elastic modulus and EFT in brucellosis patients when compared with the controls (2.46 ± 1.40 vs 1.71 ± 0.61, P = 0.016; 9.69 ± 6.99 vs 2.14 ± 0.72, P < 0.001; 11.17 ± 8.60 vs 2.18 ± 0.90, P < 0.001; 0.76 ± 0.08 vs 0.63 ± 0.10, P < 0.001). On the other hand, there was a significant decrease in aortic strain and aortic distensibility (7.41 ± 6.82 vs 18.26 ± 5.83, P < 0.001; 1.83 ± 1.71 vs 5.22 ± 1.72, P < 0.001, respectively). No difference was observed between the two groups with respect to the left ventricular myocardial performance index (MPI) (0.62 ± 0.15 vs 0.61 ± 0.13, P = 0.859). Conclusions: In this study, we demonstrated for the first time in the literature that there was impaired aortic elasticity and increased EFT in patients with brucellosis, while the myocardial performance index remained unaffected. We also determined that these effects had a significant correlation with inflammation. |
