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Document Details : Title: Circulating adiponectin: a cardiometabolic marker associated with global cardiovascular risk Author(s): T. Di Chiara , C. Argano , A. Scaglione , S. Corrao , A. Pinto , R. Scaglione Journal: Acta Cardiologica Volume: 70 Issue: 1 Date: 2015 Pages: 33-40 DOI: 10.2143/AC.70.1.3064591 Abstract : Objective: This study was designed to evaluate the relationship among circulating adiponectin (ADPN), left ventricular mass (LVM) and cardiometabolic comorbidities in subjects at higher global cardiovascular risk (score of 'Cuore Project'). Methods: 115 consecutive subjects were grouped according to normal or low ADPN levels. Left ventricular internal diameter (LVID/h), total LV mass (LVM), LVM index (LVMI), relative wall thickness (RWT), LV ejection fraction by echocardiography and diastolic parameters, by pulsed-wave Doppler were calculated. Results: Low-ADPN subjects were characterized by a significantly higher prevalence of some cardiometabolic comorbidities (obesity, visceral obesity, diabetes and insulin resistance, LVH, metabolic syndrome (MetS), coronary artery syndrome (CAD). BMI (P < 0.0001), WHR (P < 0.03), triglycerides (P < 0.001), HOMA-IR (P < 0.001), LVM, LVMI, IVST and RWT (P < 0.0001) were signifi cantly higher and HDL-C (P < 0.001) and LVEF were signifi cantly lower in low-ADPN than in normal-ADPN subjects. LVMI correlated directly with BMI (P < 0.001), WHR (P < 0.001) MBP (P < 0.001), MetS (P < 0.001) and inversely with ADPN (P < 0.0001). Multiple regression analysis indicated that ADPN was independently associated with LVMI. Conclusions: ADPN might be considered a key component mediating the cross-talk between adipose tissue, cardiac cells and the vasculature. Accordingly, its routine measurement might become a new target in the management of global CV risk. |
