 previous article in this issue | next article in this issue  |
|
Document Details : Title: Treating humoral rejection after cardiac transplantation Author(s): J. Verheyen , T. Vermeulen , K. Janssen-Van Doorn , C. Vrints , V. Conraads Journal: Acta Cardiologica Volume: 66 Issue: 2 Date: 2011 Pages: 263-266 DOI: 10.2143/AC.66.2.2071263 Abstract : Whereas effective strategies are available to treat acute cellular cardiac rejection, humoral rejection, also called vascular or antibody-mediated rejection, is more difficult to manage. Antibody-mediated (non-cellular) rejections (AMR) are rare and few successfully treated cases have been described in the literature. We report on a female patient, diagnosed with humoral rejection, leading to severe ventricular dysfunction and haemodynamic compromise, two months after transplantation. The patient received a combination therapy, consisting of plasmapheresis and immunoglobulins, which resulted in complete resolution of immunohistochemical signs of AMR. In this report, we will overview AMR and discuss several treatment modalities. |
