 previous article in this issue | next article in this issue  |
|
Document Details : Title: HbSC hemoglobinopathy suspected by chest X-ray and red blood cell morphology Author(s): THOMA J, KUTTER D, CASEL S, ROSOUX P, BRAAS C, RIES F, GROFF P, KALMES G, GOLINSKA B Journal: Acta Clinica Belgica Volume: 60 Issue: 6 Date: 2005 Pages: 377-382 DOI: 10.2143/ACB.60.6.2050489 Abstract : Thorax scan was performed for elucidation of a pulmonary problem in a Nigerian immigrant. The aspect of the vertebrae suggested sickle cell disease, of course without specification of the genotype. Routine hematological tests seemed compatible with an HbSC disease, showing typical laboratory features, namely a significant proportion of hyperchromic RBC, corresponding to secondary, non hereditary spherocytosis, presence of numerous target cells and occasional HbC crystals on Pappenheim stained blood films. The diagnosis of HbSC disease was confirmed by HPLC, iso-electric focusing and citrate agar electrophoresis of hemoglobin and by reverse phase HPLC of globin-chains. This case illustrates the importance of screening for hemoglobin anomalies as it is performed in a multi-ethnic country such as the Grand Duchy of Luxembourg |
