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Document Details : Title: Evaluation of the Stratus® CS fluorometer for the determination of plasma myoglobin Author(s): COUCK P, CLAEYS R, VANDERSTRAETEN E, GORUS FK Journal: Acta Clinica Belgica Volume: 60 Issue: 2 Date: 2005 Pages: 75-78 DOI: 10.2143/ACB.60.2.2050446 Abstract : Circulating myoglobin is recognized as an early and sensitive marker of acute coronary diseases. Long turnaround time of myoglobin assays jeopardize their clinical utility. We evaluated the analytical performance of the Stratus® CS fl uorometric enzyme immunoassay based on dendrimer technology, and claimed to achieve a fast and reliable determination of plasma myoglobin concentrations. Precision complied with the recommended analytical performance criteria. Method comparison and recovery experiments indicated, that despite good between-method correlations, the Stratus® CS method overestimated myoglobin concentrations in comparison with values obtained on Cobas® Integra 400 and BN™A. However, since the manufacturers’ cut-off for elevated plasma myoglobin levels was higher for Stratus® CS than for other techniques, few discrepant results were observed between methods. Elevated levels of hemoglobin, triglycerides and rheumatoid factors did not interfere in the Stratus® CS method but hyperbilirubinemia caused a positive difference. |
