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Document Details : Title: Atypical systemic lupus erythematosus or Castleman's disease Author(s): VAN DE VOORDE K, DE RAEVE H, DE BLOCK CE, VAN REGENMORTEL N, VAN OFFEL JF, DE CLERCK LS, STEVENS WJ Journal: Acta Clinica Belgica Volume: 59 Issue: 3 Date: 2004 Pages: 161-164 DOI: 10.2143/ACB.59.3.2050400 Abstract : Collagen vascular diseases and malignancies have common systemic and immune features. We report a case of a 21-year-old female patient with constitutional symptoms, polyserositis, spontaneous rupture of the spleen, leukocytoclastic vasculitis and acute renal failure. The tentative diagnosis of SLE was made because she developed a positive antinuclear factor (1/640), with anti-SSA antibodies and a positive lupus anticoagulans. Two months later a cervical lymphadenopathy occurred while recieving treatment with prednisolone. A lymph node biopsy revealed morphologic features of a SLE, similar to those observed in multicentric Castleman’s disease (MCD). MCD is a distinct type of a lymphoproliferative disorder of unknown etiology. The difficulties in differential diagnosis of these two diseases are discussed. |
