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Document Details : Title: Age-related change of serum angiogenic factor levels in patients with coronary artery disease Author(s): R. Meng , Z. Pei , B. Chen , R. Ma , C. Zhang , B. Chen , A. Zhang , T. Wu , D. Liu , Y. Dong Journal: Acta Cardiologica Volume: 64 Issue: 6 Date: 2009 Pages: 735-740 DOI: 10.2143/AC.64.6.2044736 Abstract : Objective — Vascular endothelial growth factor (VEGF), angiopoietin (Ang)-1 and -2 regulate angiogenesis and might be important in myocardial collateral development. Elevated levels of angiogenic growth factors in patients with coronary artery disease (CAD) have been reported. However, the age-related change of angiogenic growth factors in patients with CAD remains unclear. Methods and results — Serum VEGF, Ang-1 and -2 levels were measured by enzyme-linked immunosorbent assay kits. Serum VEGF, Ang-1 and -2 levels in patients with CAD were significantly higher than those in healthy control subjects. In patients aged < 61 years and 61 to 70 years, serum Ang-1 and -2 levels were significantly higher than in patients aged > 70 years, serum Ang-2 levels in patients aged < 61 years were significantly higher than in patients aged from 61 to 70 years. Serum VEGF levels were not significantly different in the three age groups. Serum VEGF, Ang-1 and -2 levels were not significantly different across the age groups in healthy subjects. Regression analysis showed that there was a negative correlation between age and Ang-1 and -2 in patients with CAD. Conclusion — Serum Ang-1 and -2 levels, but not VEGF levels in patients with CAD, are decreased along with advancing age. |
