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Document Details : Title: Aortic root dilatation is associated with carotid intima-media thickness but not with carotid plaque in hypertensive men Author(s): J.-J. Jiang , X.-F. Chen , X.-M. Liu , L.-J. Tang , X.-F. Lin , Z.-X. Pu , T.-L. Chen , Y. Zhang , Y.-P. Wang , J.-A. Wang Journal: Acta Cardiologica Volume: 64 Issue: 5 Date: 2009 Pages: 645-651 DOI: 10.2143/AC.64.5.2042695 Abstract : Background — The role of atherosclerosis-related processes in aortic root dilatation (ARD) has not been fully determined. The present study was to assess the relationship between carotid IMT, carotid plaque, and ARD. Methods — Hypertensive men with ARD (n = 30) were compared with hypertensive men without ARD (n = 52) and normal control subjects (n = 29). Two-dimensional echocardiography was used to measure the aortic root at the aortic annulus, the sinus of Valsalva, the sinotubular junction and the proximal part of the ascending aorta. Carotid IMT and carotid plaque were also assessed by ultrasound. Results — The measured mean carotid IMT was significantly increased in patients with ARD (1.37 ± 0.80 mm) compared to the subjects without ARD (1.06 ± 0.54 mm) and healthy control subjects (0.84 ± 0.44 mm) (P < 0.05). However, no significant differences of the prevalence of carotid plaque were found in the three groups (P > 0.05). Aortic diameters at all levels except for the diameter of the supra-aortic ridge were significantly related to carotid IMT when the hypertensive population was considered (P < 0.05). No significant correlation was found between carotid plaque and aortic root dimension (P > 0.05). Conclusion — This study shows that carotid intima-media thickening, but not carotid atherosclerotic plaque, is positively associated with ARD. Further studies to explore the underlying mechanism are awaited. |
