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Document Details :

Title: Improved myocardial perfusion preceding clinical response on bosentan treatment for coronary vasospasm
Author(s): I.A.C. Vermeltfoort , P.G.H.M. Raijmakers , P.W. Kamphuisen
Journal: Acta Cardiologica
Volume: 64    Issue: 3   Date: 2009   
Pages: 415-417
DOI: 10.2143/AC.64.3.2038032

Abstract :
Many patients suffer from persistent angina due to coronary vasospasm despite optimal medical treatment.
We treated a 46-year-old patient with severe and treatment-resistant coronary vasospasm with the endothelin-receptor antagonist bosentan. Using oxygen-15-labelled water in conjunction with oxygen 15-labelled carbon monoxide positron emission tomography (PET), we measured an impaired coronary flow reserve (CFR) in 6 out of 13 segments directly before the start of bosentan therapy. A repeated PET measurement after 16 weeks of bosentan revealed a completely normalized CFR in this patient. Furthermore, the patient reported less frequent and less severe chest pain. Our data suggest a potential role of endothelin-receptor antagonists for patients with severe coronary vasospasms.