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Title: Association between -455G/A and fibrinogen in a Chinese population
Author(s): A. Sun , H. Ma , D. Xu , Y. Wang , M. Liu , L. Xu , J. Chen , T. Hu , Z. Wang , K. Wang , Y. Zou , W. Huang , J. Ge
Journal: Acta Cardiologica
Volume: 64    Issue: 3   Date: 2009   
Pages: 357-361
DOI: 10.2143/AC.64.3.2038022

Abstract :
Objective — The aim of the study was to evaluate the association between β-fibrinogen gene -455G/A polymorphism and the plasma fibrinogen level in Chinese patients with different subtypes of coronary heart disease (CHD).
Methods and results — We investigated β-fibrinogen gene -455G/A polymorphism and plasma fibrinogen level in non-CHD control subjects (n = 466) and CHD patients (n = 1,019) including patients with stable angina pectoris (SAP) (n = 674), and acute coronary syndrome (ACS) (n = 345). Increased plasma fibrinogen levels were observed in the CHD groups compared with the control
subjects (ACS: 380.92 ± 92.35 mg/dl, SAP: 352.49 ± 94.89 mg/dl, control: 311.72 ± 87.09* mg/dl, *P < 0.001 vs. ACS and SAP). Individuals with the -455A/A genotype were associated with the highest plasma fibrinogen in the control subjects (P < 0.001) and patients with SAP (P < 0.001) but
not in patients with ACS (P > 0.05). Allele frequency and genotype distribution were similar among the three groups (P = 0.314).
Conclusions — This study demonstrated that elevated plasma fibrinogen level is related to increased CHD risk. The presence of -455A allele is significantly associated with higher fibrinogen in non-CHD control subjects and SAP patients but not in ACS patients while -455G/A polymorphism is not a risk factor for CHD in the Chinese population.

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