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Title: Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity
Author(s): M. Ebrahimi , M. Ghayour- Mobarhan , S. Rezaiean , M. Hoseini , S.M.R. Parizade , F. Farhoudi , S.J. Hosseininezhad , S. Tavallaei , A. Vejdani , M. Azimi-Nezhad , M.T. Shakeri , M.A. Rad , N. Mobarra , S.M.R. Kazemi-Bajestani , G.A.A. Ferns
Journal: Acta Cardiologica
Volume: 64    Issue: 3   Date: 2009   
Pages: 321-327
DOI: 10.2143/AC.64.3.2038016

Abstract :
Objective — Fish-oil contains high concentrations of omega-3 fatty acids that have been shown to have anti-inflammatory properties. We have evaluated the effects of purified omega-3 fatty acid supplements on several anthropometric and biochemical parameters, including heat shock protein (Hsp)
27 antibody titres in subjects with metabolic syndrome.
Methods — Subjects (n = 120) with metabolic syndrome (mean age of 52.9 ± 11.9 years) were randomly allocated to one of two groups: sixty subjects were given 1 gram of fish oil as a single capsule, containing 180 mg eicosapentaenoic acid and 120 mg docosahexaenoic acid daily for 6 months. Control subjects did not receive any supplementation over the same period.
Results — The study was completed by 47 subjects in the intervention group and 42 subjects in the control group. Treatment with omega-3 supplements was associated with a significant fall in body weight (P < 0.05), systolic blood pressures (P < 0.05), serum low density lipoprotein cholesterol (P < 0.05), and total cholesterol (P < 0.05), triglycerides (P < 0.05), high-sensitivity C-reactive protein (hs-CRP) (P < 0.01), and Hsp27 antibody titres (P < 0.05). No significant changes were observed in the control group.
Conclusion — It appears that omega-3 improves the cardiovascular risk profile of subjects with metabolic syndrome, having effects on weight, systolic blood pressure, lipid profile and markers of inflammation and autoimmunity.

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