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Document Details : Title: Association between paraoxonase 1 activity and severity of coronary artery disease in patients with acute coronary syndromes Author(s): T. Sentürk , E. Sarandöl , S. Güllülü , S. Erdinç , B. Özdemir , I. Baran , A. Aydinlar Journal: Acta Cardiologica Volume: 63    Issue: 3   Date: 2008    Pages: 361-367 DOI: 10.2143/AC.63.3.1020314 Abstract : Objective — We sought to investigate serum paraoxonase/arylesterase activities in patients with acute coronary syndromes (ACS) and their correlations with the severity and extent of coronary artery disease (CAD). Methods and results — Three groups of patients were investigated: 89 patients with ACS, 54 patients with normal coronary angiograms (no-CAD group), and 27 healthy comparison subjects. ACS patients were divided into three groups according to their clinical presentation: unstable angina pectoris (UAP, Braunwald III-B, n = 31), non-ST elevation myocardial infarction (NSTEMI) (n= 27), and ST-elevation myocardial infarction (STEMI) (n = 31). Serum paraoxonase/arylesterase activities were measured spectrophotometrically. Angiographic CAD extent was expressed both by the number of vessels diseased and by the Gensini scoring system. Results showed that serum paraoxonase/arylesterase activities and the paraoxonase/high density lipoprotein-cholesterol (HDL-C) ratio were significantly lower in the STEMI, NSTEMI, UAP groups than in no-CAD and control groups. Serum paraoxonase/arylesterase activities and paraoxonase/HDL-C ratio were reduced in patients with 2-vessel disease (VD) and 3-VD compared to the 1-VD and no-CAD group (P < 0.001). In patients with ACS, the Gensini score correlated inversely with serum paraoxonase (r = –0.419, P < 0.001), arylesterase (r = –0.492, P < 0.0001), and the paraoxonase/HDL-C ratio (r = –0.377, P < 0.001). Serum arylesterase (r = 0.161, P = 0.03) and paraoxonase (r = 0.135, P = 0.002) activities were positively correlated with HDL-C levels. Serum arylesterase activity (P < 0.0001), gender (P = 0.0037), diabetes mellitus (P = 0.005) and LDL-C levels (P = 0.03) were independent predictors of CAD presence. Conclusions — Serum paraoxonase/arylesterase activities are reduced in ACS patients and inversely correlated with the severity of CAD.