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Title: Study of the correlation between blood lipid levels and the severity of coronary atherosclerosis in a Chinese population sample
Author(s): JIN, Zhengming , ZHANG, Yun , CHEN, Junzhu , ZHU, Jianhua , ZHANG, Furong , QIU, Yuagang , ZHAO, Lili
Journal: Acta Cardiologica
Volume: 61 Issue: 6 Date: December 2006
Objective — To investigate the relationship between blood lipid levels with severity of coronary artery atherosclerosis in a Chinese population sample.
Methods and results — According to coronary angiography results, 363 patients (287 men and 76 women) with coronary artery atherosclerosis were divided into four groups: the single-vessel group (I, n = 125), the double-vessel group (II, n = 113), the triple-vessel group (III, n = 107) and the multivessel group (IV,n = 18).The severity of coronary artery atherosclerosis was quantified with a modified Gensini score on the basis of angiographic imaging. Serum triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), non-high density lipoprotein cholesterol (non-HDL-C) were measured before angiography in all groups. Levels of serum TC, LDL-C and non-HDL-C of the II,III and IV group were significantly higher than those of the I group (4.78 ± 0.82 mmol/L and 4.87 ± 1.50 mmol/L and 4.73 ± 0.99 mmol/L vs. 4.38 ± 0.93 mmol/L, 2.91 ± 0.68 mmol/L and 2.74 ± 1.23 mmol/L and 2.64 ± 0.84 mmol/L vs. 2.30 ± 0.77 mmol/L, 3.58 ± 0.75 mmol/L and 3.59 ± 1.41 mmol/L and 3.43 ± 0.94 mmol/L vs. 3.17 ± 0.91 mmol/L; p < 0.05); the mean levels of TC, LDL-C and non-HDL-C associated positively with the Gensini score.
Conclusion — Serum lipid levels correlate positively with the severity of coronary artery atherosclerosis in a Chinese population sample. Patients with higher levels of serum TC, LDL-C and non-HDL-C have more severe coronary atherosclerosis,compared with those with low levels of serum TC, LDL-C and non-HDL-C.