|previous article in this issue||next article in this issue|
Document Details :
Title: Iron status and itts relationship with lipid peroxidation in patients with acute myocardial infarction
Author(s): BAYKAN, Merih , ÇELİK, Şükrü , ÖREM, Ası , MALKOÇ, Meltem , ERDÖL, Cevdet , BAYKAN, Emre C. , ÖREM, Cihan , KARAHAN, Burhan
Journal: Acta Cardiologica
Volume: 56 Issue: 5 Date: October 2001
Aim — The aim of this study was to investigate iron status and its relationships with lipid peroxidation in patients with acute myocardial infarction (MI).
Methods — The study included 30 male patients aged between 32 and 73 years (mean 55 ± 6) with acute MI.We measured the levels of plasma iron, transferrin (TF), ferritin (FER), ceruloplasmin (CER), cardiac enzymes, and erythrocyte malondialdehyde (e-MDA) in patients with acute MI on the admission and 1st, 3rd, 5th, 7th, 15th, 45th post MI day and investigated the variations of these parameters in acute MI.
Results — The e-MDA level started to increase on the admission day and showed a peak value on the post MI 1st day (88 ±23 and 98 ±26 nmol/g Hb,respectively). Afterwards,the e-MDA level minimally changed until post MI 45thday,which showed a minimum level (57 ±13 nmol/g Hb) (p < 0.05). In addition, the iron concentration of serum reached its maximum level on the 1st post MI day (99 ± 30 mg/dl, p < 0.05) and relatively decreased after the 3rd day.Courses of MDA and iron levels were similar. The FER level started to increase from the admission day of the patients (230 ± 375 mg/dl), showed a mean peak value on the 3rd day (296 ± 568 mg/dl) and decreased to a minimum level on the 45th day (121 ± 85 mg/dl) (p < 0.05). Contrarily,the TF level started to decrease on the 1st day (221 ± 44 mg/dl),decreased minimum level on the 3rdday (211 ± 37 mg/dl) and continued approximately the same level until the 45th day (244 ± 45 mg/dl) (p < 0.05). The CER level started to increase from the first day of admission of the patients (43 ± 12 mg/dl), reached a maximum level on the 7th day (59 ±12 mg/dl) and similar levels were observed until the 15th day.On the 45th day, the CER level was higher than on the first day (52 ± 13 mg/dl) (p < 0.05).
Conclusion — There was an association of higher iron status with increased lipid peroxidation in patients with myocardial infarction.