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Document Details : Title: The effect of atorvastatin on postprandial lipaemia in overweight or obese women homozygous for apo E3 Author(s): VANSANT, Greet , MERTENS, Ann , MULS, Erik Journal: Acta Cardiologica Volume: 56 Issue: 3 Date: June 2001 Pages: 149-154 DOI: 10.2143/AC.56.3.2005634 Abstract : Objective— To determine the effect of atorvastatin on postprandial lipaemia in overweight or obese women with the apoprotein (apo) E3/E3 genotype. Design— Double-blind randomised, placebo-controlled 8-week single-centre study. Subjects — Twenty-two healthy women, homozygous for apo E3 with a BMI ranging from 27.6 to 41.1 kg/m2 and normal or moderately elevated fasting triglycerides (53-184 mg/dl). Treatment — After a 4-week isocaloric single-blind,placebo lead-in period,subjects were randomly assigned to receive either placebo (n = 7) or atorvastatin 20 mg once daily in the evening (n = 15) for 4 weeks. Results — Atorvastatin significantly reduces fasting total cholesterol, LDL-cholesterol and post- prandial triglycerides in obese women, homozygous for apo E3 with normal or near-normal fasting triglyceride levels. No significant effect on fasting triglycerides was observed. Conclusion — Atorvastatin decreases postprandial hyperlipidaemia,an independent cardiovascular risk factor, in normolipidaemic obese women.This effect of atorvastatin may, therefore, represent a cardioprotective mechanism. |