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Document Details :
Title: The effect of atorvastatin on postprandial lipaemia in overweight or obese women homozygous for apo E3
Author(s): VANSANT, Greet , MERTENS, Ann , MULS, Erik
Journal: Acta Cardiologica
Volume: 56 Issue: 3 Date: June 2001
Objective— To determine the effect of atorvastatin on postprandial lipaemia in overweight or obese
women with the apoprotein (apo) E3/E3 genotype.
Design— Double-blind randomised, placebo-controlled 8-week single-centre study.
Subjects — Twenty-two healthy women, homozygous for apo E3 with a BMI ranging from 27.6 to 41.1 kg/m2 and normal or moderately elevated fasting triglycerides (53-184 mg/dl).
Treatment — After a 4-week isocaloric single-blind,placebo lead-in period,subjects were randomly assigned to receive either placebo (n = 7) or atorvastatin 20 mg once daily in the evening (n = 15) for 4 weeks.
Results — Atorvastatin significantly reduces fasting total cholesterol, LDL-cholesterol and post- prandial triglycerides in obese women, homozygous for apo E3 with normal or near-normal fasting triglyceride levels. No significant effect on fasting triglycerides was observed.
Conclusion — Atorvastatin decreases postprandial hyperlipidaemia,an independent cardiovascular risk factor, in normolipidaemic obese women.This effect of atorvastatin may, therefore, represent a cardioprotective mechanism.