Brain natriuretic peptide and C-type natriuretic peptide are differently regulated by age but similarly elevated in coronary artery disease

HONG, Ta-Chun; YEH, Hung-I; SHIH, Bing-Fu; WANG, An-Mei; CHEN, Chun-Yen; HOU, Charles Jia-Yin; TSAI, Cheng-Ho

Document Details :

Title: Brain natriuretic peptide and C-type natriuretic peptide are differently regulated by age but similarly elevated in coronary artery disease
Author(s): HONG, Ta-Chun , YEH, Hung-I , SHIH, Bing-Fu , WANG, An-Mei , CHEN, Chun-Yen , HOU, Charles Jia-Yin , TSAI, Cheng-Ho
Journal: Acta Cardiologica
Volume: 61 Issue: 1 Date: February 2006
Pages: 1-5
DOI: 10.2143/AC.61.1.2005133

Abstract :
Objective— We investigated the effect of age and coronary angioplasty on brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP).

Methods and results— Serum levels of both peptides immediately before catheterization and at the end of angioplasty in 15 patients (age 68±8 years, 8 men) with coronary artery disease (CAD) were compared to 12 elderly (65±7 years, 8 men) and 16 non-elderly (34±7 years,10 men) healthy individuals.The results showed that in healthy individuals the levels of both peptides are age-dependent dissimilarly. Compared to the non-elderly, while BNP increases in the elderly (7.81±1.60 vs. 10.01±2.06 pg/ml, p=0.002), CNP decreases (5.39±1.30 vs. 2.22±0.80 pg/ml, p<0.001). On the other hand,compared to the elderly healthy persons,patients with CAD have a marked increase in the baseline levels of BNP (20.02±17.43 pg/ml, p=0.03) and CNP (4.41±1.20 pg/ml, p<0.001). However, both peptides remain stationary immediately after angioplasty (BNP, 21.02±16.95; CNP, 4.51±1.06 pg/ml; both p=0.4).

Conclusions— BNP and CNP are differentially regulated by age in a healthy state,suggesting that each peptide has a distinct role during the aging process.The elevation of both peptides in CAD but little change shortly after angioplasty may indicate that both peptides respond to a chronic state rather than an acute episode of vascular damage.