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Document Details : Title: A hypogranular variant of acute promyelocytic leukemia showing a heterogenic immunophenotype with CD34, CD2, HLA-DR positivity: a case report and review of the literature Author(s): PATTEET L, VERMEULEN K, PIETERS K, VAN ASSCHE E, VRELUST I, GADDISEUR A, BERNEMAN ZN, VAN DER PLANCKEN M Journal: Acta Clinica Belgica Volume: 67 Issue: 1 Date: 2012 Pages: 34-38 DOI: 10.2143/ACB.67.1.1003041 Abstract : We report the case of a 46-year-old man who presented with the hypogranular variant of an acute promyelocytic leukaemia (APL). RT-PCR analysis for detection of the t(15;17) fusion transcript confi rmed the cytological fi ndings by demonstrating a bcr-3 type PML/RARα rearrangement. According to the WHO-classifi cation, this leukaemia fulfi lled the criteria for ‘Acute promyelocytic leukaemia with t(15;17)(q22;q12)’ (1). Immunophenotyping revealed a leukaemic population with an aberrant expression of markers. Besides the presence of the expected immunophenotypic markers in APL (CD45 with low density, CD13+, CD33+, CD15-, CD117+ and MPO+), the population showed a positivity for CD34, CD2 and HLA-DR for at least a part of the malignant promyelocytes. Since the expression of these three markers, all together, is rather unique, we reviewed the literature to prove the relationship of this specific immunophenotype with morphology, clinical and molecular findings. |
