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Document Details : Title: Late vitamin K deficiency bleeding leading to a diagnosis of cystic fibrosis: a case report Author(s): NGO B, VAN PELT K, LABARQUE V, VAN DE CASSEYE W, PENDERS J Journal: Acta Clinica Belgica Volume: 66 Issue: 2 Date: 2011 Pages: 142-143 DOI: 10.2143/ACB.66.2.1002934 Abstract : Vitamin K deficiency bleeding (VKDB) in infants still occurs despite worldwide use of prophylaxis. Clinical manifestations can be dramatic with over 50% of patients presenting with intracranial haemorrhage and a mortality rate of 20% in late vitamin K deficiency bleeding. Special attention should be given to infants with a high risk profile (preterm, breast feeding, cholestasis, malabsorption). A tentative diagnosis can be made observing quick normalisation of some easy-to-perform haemostatic parameters (PT, aPTT) after administration of vitamin K. Nowadays, VKDB can still be the first clinical sign of diseases causing malabsorption of fat-soluble vitamins. In this case report, VKDB led to the diagnosis of cystic fibrosis, the most common fatal autosomal recessive disease among Caucasian people. |
