 previous article in this issue |
|
Document Details : Title: Penicillin or vancomycin plus ceftazidime in febrile neutropenic patients after stem cell transplantation Author(s): KARGAR SAMANI K, VANDERCAM B, STRAETMANS N, MICHAUX L, FERRANT A Journal: Acta Clinica Belgica Volume: 55 Issue: 5 Date: 2000 Pages: 279-284 DOI: 10.2143/ACB.55.5.1002914 Abstract : The response of gram-positive cocci to third generation cephalosporin therapy in febrile neutropenic patients is not optimal. We evaluated the safety and efficacy of ceftazidime plus penicillin (C+P) and compared it to ceftazidime plus vancomycin (C+V) in febrile neutropenic patients. The study includes 64 patients admitted to the Department of Haematology. Thirty-six patients were treated with C+V and 28 patients with C+P. Control of infection was observed in 78% of the patients in the C+V group and in 57% of the patients in C+P group (p = 0.5). Infection was the cause of the death of 1 patient in each group. We conclude that the combination of C+P has the same activity as the combination of C+V in febrile neutropenic patients. The morbidity and mortality were identical in both groups but cost effectiveness was in favour of the C+P group. |
