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Document Details : Title: Clinical, biophysical and biochemical variables from African-heritage subjects with type 2 diabetes Author(s): HERMANS MP, DUMONT C, BUYSSCHAERT M Journal: Acta Clinica Belgica Volume: 57 Issue: 3 Date: 2002 Pages: 134-141 DOI: 10.2143/ACB.57.3.1002793 Abstract : We compared the metabolic profile of two ethnic populations with type 2 diabetes, one from Bantu (n=23; Ban) and the other from Belgian (n=314) extraction followed at St Luc Hospital. Further comparison with a Belgian sub-cohort (n=64; Be) matched for age (52 yrs) and sex distribution (M/F : 61/39 %) showed no significant difference between Belgian and Bantu subjects with regards to diabetes duration (9 and 11 yrs; Ban and Be respectively), age at diabetes diagnosis (43 and 42 yrs), HbA1c (8.1±1.9 vs. 8.5±1.9 %; NS), and achieved education level. BMI was lower in Ban (29±4 vs. 32±7 in Be; p<0.02), as were body fat (33±12 vs. 37±11 kg; NS) and waist diameter (99±9 vs. 106±16 cm; p<0.02). Forty-eight and 72% of Ban and Be were on metformin (p<0.05), while insulin was given to 39 and 34%. Daily insulin dose was lower in Ban (0.31±0.20 vs. 0.47±0.18 IU.kg-1.24h-1; p<0.001). There was no difference in ß-cell function (%ß; normal: 100%) or insulin sensitivity (%S; normal :100%) as determined with HOMA between groups. %ß (median [perc 25-75]) was 51 [23-119] and 67 [45-84] in Ban and Be, while %S was 32 [29-37] and 37 [27-45]. Smoking (past & current) prevalence was 5 and 47% in Ban and Be (p<0.0001). Prevalence of micro- and macroangiopathy did not differ between groups, although Ban had more macroalbuminuria (29 vs. 9 %; p<0.05), and were more often treated with Ca2+-channel- and ß-blockers than Be subjects (36 and 39 % vs. 16 and 8 %; p= 0.07 and <0.05, respectively). Fasting (F) and interprandial (IP) triglycerides (TG) were lower in Ban : 115 [81-149] vs. 189 [155-325] mg.dL-1 for F-TG and 127 [81-160] vs. 170 [128-305] mg.dL-1 for IP-TG (p<0.0001), as was total cholesterol (201±53 vs. 223±40 mg.dL-1 (p<0.05), despite lower use of hypolipidaemic drug (13 vs. 44%; p<0.01). Africanheritage subjects with type 2 diabetes have similar degree of diabetes control and complications, in the presence of leaner biophysical status, minimal tobacco exposure and lower fasting and interprandial triglycerides. |
