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Document Details : Title: Coriander anaphylaxis in a spice grinder with undetected occupational allergy Author(s): EBO DG, BRIDTS CH, MERTENS MH, STEVENS WJ Journal: Acta Clinica Belgica Volume: 61 Issue: 3 Date: 2006 Pages: 152-156 DOI: 10.2143/ACB.61.3.1002686 Abstract : Background: Anaphylaxis after ingestion of spices as a result from occupational sensitization remains anecdotal. We describe a patient, working in a spice factory, with anaphylaxis from coriander in a meal. He also demonstrated urticaria, angio-edema, rhinoconjunctivitis and bronchospasm during handling coriander and fenugreek. Objective: To determine the mechanism of the anaphylactic reaction and to evaluate cross-reactivity between both botanically unrelated spices. Methods: Investigations comprised quantification of total and specifi c IgE by Immuno-CAP FEIA, skin testing, basophil activation experiments by flow-assisted determination of CD63 expression in the patient and 3 healthy controls. Immuno-CAP inhibition experiments were applied to investigate cross-reactivity. Results: Specific IgE, skin tests and basophil activation tests were clearly positive in the patient, whereas they remained negative in controls. No cross-reactivity between fenugreek and coriander was demonstrable by inhibition experiments. Conclusions: The clinical manifestations in temporal relationship to ingestion of coriander and handling of coriander and/or fenugreek, the positive specific IgE results, skin tests and basophil activation assays support the diagnosis of allergy to both spices. History suggests sensitization by occupational exposure. |
