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Document Details : Title: Mycobacterium avium complex with a distinct clinical and iconographic presentation: the Lady Windermere Syndrome Author(s): GOEMINNE H, PELEMAN RA, BRUSSELLE G, TOURNOY KG Journal: Acta Clinica Belgica Volume: 61 Issue: 2 Date: 2006 Pages: 79-81 DOI: 10.2143/ACB.61.2.1002678 Abstract : Clinically significant pulmonary disease caused by non-tuberculous mycobacteria such as Mycobacterium avium Complex (MAC) usually occurs upon preexisting lung diseases or immune-deficiency. In 1992, a particular presentation of pulmonary MAC, occuring in otherwise healthy middle-aged women, was described with pulmonary consolidations localized in lingula and middle lobe. For this specific, rare condition, the term Lady Windermere syndrome was introduced. We report a particular case of this syndrome, in which an otherwise healthy individual developed clinically significant disease upon MAC (subtype: Mycobacterium avium) infection of the right middle lobe of the lung. The patient did not have the classical risk factors for developing this syndrome (e.g. habitual cough suppression, long and narrow bronchi) indicating their modest contribution in the pathogenesis. In our case, guideline based therapy was found to be inadequate because of multi-drug resistance, so an alternative treatment regime was given with good clinical result. |
