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Document Details : Title: Portal vein thrombosis in a patient with HIV treated with a protease inhibitor-containing regimen Author(s): SOENTJENS P, OSTYN B, VAN OUTRYVE S, YSEBAERT D, VEKEMANS M, COLEBUNDERS R Journal: Acta Clinica Belgica Volume: 61 Issue: 1 Date: 2006 Pages: 24-29 DOI: 10.2143/ACB.61.1.1002669 Abstract : We report a case of an HIV seropositive female patient treated with a protease inhibitor-containing regimen who developed recurrent severe life-threathening episodes of haematemesis over time, caused by ruptured oesophageal varices as a consequence of a portal vein thrombosis. Coagulation tests revealed a protein S deficiency, an elevated homocysteinemia and a constitutional elevated plasma factor VIII coagulant activity. These coagulopathies and the HIV infection are independent risk factors for developing venous thromboembolic events. The protease inhibitor treatment may have played a role in increasing the thromboembolic risk. The recurrent bleedings only stopped after invasive surgery. The invasive splenorenal shunt operation was in this case a life-saving procedure. |
