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Document Details : Title: Acute myeloid leukaemia of mixed megakaryocytic and erythroid origin: a case report and review of the literature Author(s): DANIËLS L, GUERTI K, VERMEULEN K, DE RAEVE H, VAN ASSCHE E, VAN DE VELDE AL, BERNEMAN ZN, VAN DER PLANKEN M Journal: Acta Clinica Belgica Volume: 62 Issue: 5 Date: 2007 Pages: 308-314 DOI: 10.2143/ACB.62.5.1002650 Abstract : We report the case of a 78-year-old man who presented with acute myeloid leukaemia showing subpopulations of cells expressing platelet-associated markers and the presence of a pan-myeloid component, besides glycophorin A-positive cells. Most of the immature cells had a proerythroblastlike morphology and we classified this case as an FAB-M6 variant, as suggested by Bain (1). According to the WHO classification, this leukaemia fulfilled the criteria of ‘AML with multilineage dysplasia’ (2). Immunophenotyping characteristics showed two distinct aberrant subpopulations, a young panmyeloid (CD45+ with low density, CD34+, CD117+, CD13+, CD33+, partial cytoplasmic myeloperoxidase (MPO)+) population with platelet-associated markers (CD41+, CD42+, CD61+) and a CD45+, CD117+, CD34- population with partial CD235a positivity indicative for erythroid maturation. This case belongs to the group of ‘early’ erythroblastic leukaemias where a subset of progenitor cells present with erythroid-megakaryocyte bipotentiality or are blocked at an early BFU-E (burst-forming unit erythrocyte)-like stage of erythroid differentiation (11, 12, 13). |
