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Document Details : Title: Drug hypersensitivity Author(s): YAWALKAR N Journal: Acta Clinica Belgica Volume: 64 Issue: 6 Date: 2009 Pages: 529-533 DOI: 10.2143/ACB.64.6.1002532 Abstract : Drug hypersensitivity represents an immunemediated reaction to a drug. Although several drug hypersensitivity reactions are confined to the skin and rather mild, some may be life threatening and also involve further organs such as liver, kidney and bone marrow. The exact pathogenesis of many drug hypersensitivity reactions is still obscure. In this review the concepts on how small molecular drugs can activate the immune system are discussed and the hapten, prohapten and p-i concept are explained. Furthermore, the classification of drug hypersensitivity reactions and some common and severe clinical manifestations of drug-induced T cell mediated reactions are presented. |
