 previous article in this issue | next article in this issue  |
|
Document Details : Title: Angioedema beyond histamine: an educational case series Author(s): DE KNOP KJ, HAGENDORENS MM, STEVENS WJ, DE CLERCK LS, EBO DG Journal: Acta Clinica Belgica Volume: 64 Issue: 6 Date: 2009 Pages: 520-528 DOI: 10.2143/ACB.64.6.1002531 Abstract : Angioedema constitutes an important clinical problem that can cause significant morbidity and mortality. Correct management requires a prompt recognition and treatment of the acute event and identification of the underlying cause. Many cases are caused by non-allergic reactions and do not result from mediator release by degranulating mast cells and basophils, but are related to accumulation of plasma and tissue bradykinin. This case series aims primarily to describe some important causes of non-allergic bradykinin-induced angioedema. Particular emphasis is put on clinical particularities, differential diagnosis, diagnostic approach and correct therapeutic management, as bradykinin-mediated angioedema is unresponsive to antihistamines. |
