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Document Details : Title: Common variable immunodeficiency (CVID): case report and review of the literature Author(s): ROELANDT PR, BLOCKMANS D Journal: Acta Clinica Belgica Volume: 64 Issue: 4 Date: 2009 Pages: 355-360 DOI: 10.2143/ACB.64.4.1002504 Abstract : Common variable immunodeficiency (CVID) is an immunodeficiency disease characterized by diminished ability to produce immunoglobulins. CVID has an estimated incidence of 1:10.000 to 1:200.000 (male:female 1:1) and usually presents in the second and third decade, although it also has a peak of incidence in childhood. The exact pathophysiology remains unclear. CVID can be associated with autoimmune, granulomatous and gastrointestinal diseases and patients have a predisposition to malignancies (especially non-Hodgkin lymphoma). Since different organ systems can be affected, all clinicians need to be aware of this entity, especially when confronted with patients with recurrent infections and/or multiple autoimmune diseases. |
