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Title: Intravascular large B-cell lymphoma of the uterus presenting as fever of unknown origin (FUO) and revealed by FDG-PET
Author(s): LANNOO L, SMETS S, STEENKISTE E, DELFORGE M, MOERMAN P, STROOBANTS S, KNOCKAERT D, AMANT F
Journal: Acta Clinica Belgica
Volume: 62 Issue: 3 Date: 2007
Non-Hodgkin’s lymphoma (NHL) is a common cause of Fever of Unknown Origin (FUO) but the presentation as a gynaecologic malignancy is exceedingly rare. To our knowledge, this represents the first report of an intravascular large B-cell lymphoma of the uterus presenting with fever of unknown origin. After a standard clinical work-up for FUO, the endometrial curettage directed by the finding of a localized fluoro-deoxyglucose Positron Emission Tomography (FDG-PET) hot spot in the pelvic area, yielded material revealing an intravascular B-cell lymphoma. A total abdominal hysterectomy confi rmed the presence of an intravascular large B-cell lymphoma in the lumina of small blood vessels of the uterus.