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Document Details : Title: An unusual form of Naxos disease and its improvement by adjuvant low-dose colchicine therapy Author(s): N. Gultekin , E. Kucukates Journal: Acta Cardiologica Volume: 68 Issue: 4 Date: 2013 Pages: 433-437 DOI: 10.2143/AC.68.4.2988900 Abstract : We evaluated a female patient with an unusual form of Naxos disease, who presented with central cyanosis and clubbing, simulating congenital heart disease. Adjuvant low-dose colchicine therapy (0.5 mg once daily) showed positive effects and has been continued for six months. Colchicine has anti-inflammatory and anti-fibrotic properties. It inhibits mitosis by disrupting tubulin assembly and enhances cellular apoptosis. Follow-up showed improvement in the patient’s clinical status, with a dramatic disappearance of the electrical storm and reductions in cyanosis and palmoplantar hyperkeratosis. Low-dose colchicine may be safe and effective in patients with Naxos disease and may reduce related complications. |
