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Title: Comparison of restenosis rate with sirolimus-eluting stent in STEMI patients with and without diabetes at 6-month angiographic follow-up
Author(s): S. Ma , D. Yang , X. Zhang , B. Tang , D. Li , M. Sun , Y. Yang
Journal: Acta Cardiologica
Volume: 66    Issue: 5   Date: 2011   
Pages: 603-606
DOI: 10.2143/AC.66.5.2131085

Abstract :
Objective: Patients with diabetes mellitus (DM) are at high risk for restenosis after coronary stenting. However, whether drug-eluting stents are effective in diabetic patients presenting with ST-segment elevation myocardial infarction (STEMI) is uncertain. We report on a series of patients with or without DM followed up for 6 months after sirolimus-eluting stent implantation.
Methods: This cohort study enrolled 195 STEMI patients who underwent sirolimus-eluting stent implantation and accepted angiographic followup at 6 months.
Results: There were no significant differences between the two groups in baseline clinical characteristics and risk factors. The two groups were treated with similar stent lengths and diameters. The unadjusted in-stent restenosis was significantly higher in diabetic than in non-diabetic patients at 6 months (7.8 vs 1.7, P < 0.05). Multivariate analysis showed that only diabetes and current smoking were independent predictors of restenosis (odds ratio 12.82 and 7.98, respectively, both P < 0.05).
Conclusion: The present study demonstrated that diabetes increased restenosis after sirolimus-eluting stent placement in STEMI patients. This finding implicates that diabetes remains an important predictor for restenosis in the DES era.

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