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Document Details : Title: Retinoic acid prevents ventricular remodelling induced by tobacco smoke exposure in rats Author(s): L.C. Oliveira , P.S. Azevedo , M.F. Minicucci , B.P.M. Rafacho , D.R. Duarte , L.S. Matsubara , B.B. Matsubara , S.A.R. Paiva , L.A.M. Zornoff Journal: Acta Cardiologica Volume: 66 Issue: 1 Date: 2011 Pages: 3-7 DOI: 10.2143/AC.66.1.2064960 Abstract : Objective: Our objective was to test the hypothesis that retinoic acid supplementation could attenuate ventricular remodelling induced by tobacco smoke exposure in rats. Methods and results: Wistar rats were allocated into three groups: control (C, n = 8); exposed to tobacco smoke (ETS, n = 9); exposed to tobacco smoke and all-trans-retinoic acid (ETS-RA, n = 9). After two months, cardiac function and geometry were assessed by echocardiography, and geometry changes were confirmed by morphometric analysis. Data are expressed as mean ± SD or medians (including the lower quartile and upper quartile). ETS showed higher normalized left ventricular diastolic diameters than groups C and ETS-RA (C = 18.4 ± 3.57 mm/kg, ETS = 23.0 ± 1.8, ETS-RA = 19.5 ± 0.99; P < 0.05) and systolic diameters (C = 8.25 ± 2.16 mm/kg, ETS = 11.5 ± 1.31, ETS-RA = 8.25 ± 0.71 mm/kg; P < 0.05). ETS showed reduced ejection fraction (C = 91 ± 2.0, ETS = 87 ± 3.0, ETS-RA = 92 ± 3.0; P < 0.05) and fractional shortening (C = 55.8 ± 4.41 %, ETS = 49.7 ± 4.43 %, ETS-RA = 57.6 ± 5.15 %; P = 0.01) compared to C and ETS-RA. ETS had increased myocyte cross-sectional area (C = 294 ± 21 mm2, ETS = 352 ± 44, ETS-RA = 310 ± 35; P < 0.05) compared to C and ETS-RA. Considering all variables, there were no differences between groups C and ETS-RA. Conclusion: Retinoic acid prevented ventricular remodelling induced by tobacco smoke exposure. |
