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Document Details : Title: Calciphylaxis in a cardiac patient without renal disease Author(s): A. Almafragi , J. Vandorpe , K. Dujardin Journal: Acta Cardiologica Volume: 64 Issue: 1 Date: 2009 Pages: 91-93 DOI: 10.2143/AC.64.1.2034368 Abstract : Calciphylaxis is a rare complication that occurs in 1% of patients with end-stage renal disease (ESRD) each year. Extensive microvascular calcification and occlusion/thrombosis lead to violaceous skin lesions, which progress to nonhealing ulcers with secondary infection, often leading to sepsis and death. The lower extremities are predominantly involved (roughly 90% of patients). Although most calciphylaxis patients have abnormalities of the calcium-phosphate axis or elevated levels of parathyroid hormone, these abnormalities do not appear to be fundamental to the pathophysiology of the disorder. We report on a case of histologically proven calciphylaxis in a 54-year-old woman with normal renal function and normal calcium-parathyroid homeostasis. She had a history of alcoholic cardiomyopathy, and was treated with warfarin anticoagulation. She has been successfully treated with antibiotics, i.v. biophosphonates and intensive locale wound care.We recorded a complete wound healing in contrast to what is reported in other series. |