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Document Details : Title: Effect of phosphodiesterase III inhibitor on plasma concentrations of endothelin-1 and tumour necrosis factor in patients with acute heart failure Author(s): NAKAMURA, Tsukasa , SUZUKI, Shingo , USHIYAMA, Chifuyu , SHIMADA, Noriaki , KOIDE, Hikaru Journal: Acta Cardiologica Volume: 57 Issue: 1 Date: February 2002 Pages: 19-21 DOI: 10.2143/AC.57.1.2005374 Abstract : Objective — Effects of loprinone hydrochloride on plasma ET-1 and TNF-alevels were assessed in patients with acute heart failure (AHF). Methods and results — Thirty patients with AHF were divided into 2 groups and treated with loprinone hydrochloride (0.3 μg/kg/min) (n = 15) or placebo (n = 15). Twenty healthy controls were also included. Plasma ET-1 and TNF-awere significantly higher in the 30 AHF patients than in the healthy controls. In AHF patients, loprinone hydrochloride lowered plasma ET-1 and TNF-a(p < 0.01). Conclusion — ET-1 and TNF-amay play pathophysiological roles in the progression of AHF. Loprinone hydrochloride is effective in reducing plasma ET-1 and TNF-alevels in AHF patients. |
