 previous article in this issue | next article in this issue  |
|
Document Details : Title: The relationship between preprocedural platelet size and subsequent in-stent restenosis Author(s): NORGAZ, Tugrul , HOBIKOGLU, Gultekin , AKSU, Huseyin , BOLCA, Osman , UYAREL, Huseyin , EREN, Mehmet , NARIN, Ahmet Journal: Acta Cardiologica Volume: 59 Issue: 4 Date: August 2004 Pages: 391-395 DOI: 10.2143/AC.59.4.2005204 Abstract : Objective — Elevated mean platelet volume predicts restenosis after percutaneous transluminal coronary angioplasty but its effect on the development of in-stent restenosis is not known. We assessed the effect of mean platelet volume measured before coronary stent implantation for stable angina pectoris on subsequent development of in-stent restenosis. Methods and results — We retrospectively analysed the data of 60 patients who had stent implantation on one native coronary artery for stable angina pectoris and control angiographies for clinically suspected restenosis within 6 months. Mean platelet volume was measured by auto analyzer one day before stent implantation. Clinical and demographic data and laboratory results were obtained from the hospital charts of the patients. In-stent restenosis was evaluated visually from control angiograms. Angiographic in-stent restenosis was present in 35 (58%) of 60 patients and 25 (42%) patients had no restenosis. Mean platelet volume in the in-stent restenosis group was 8.28 ± 0.71 fl compared to 7.63 ± 0.74 fl in the no-restenosis group (p = 0.001). There was a positive correlation between preprocedural mean platelet volume and development of in-stent restenosis (r = 0.44; p < 0.001). A mean platelet volume value of ? 8.4 fl was associated with an odds ratio of 16.0 for development of in-stent restenosis, with high specificity and positive predictivity but poor sensitivity and negative predictivity (96%, 93%, 40% and 53%, respectively). Conclusions — Mean platelet volume measured before stent implantation is correlated with subsequent development of in-stent restenosis. If preprocedural mean platelet volume is greater than 8.4 fl, in-stent restenosis is more probable to occur. |
