previous article in this issue | next article in this issue |
Document Details : Title: The heart in sickle cell disease Author(s): TSIRONI, Maria , AESSOPOS, Athanasios Journal: Acta Cardiologica Volume: 60 Issue: 6 Date: December 2005 Pages: 589-598 DOI: 10.2143/AC.60.6.2004929 Abstract : Cardiovascular abnormalities are often apparent in sickle cell disease, as in other chronic anaemias. Tissue oxygen extraction and cardiac output are increased, while the activated endothelium along with the sickling process and the vaso-occlusion of the small blood vessels strain further the cardiovascular system. Evidence for a specific myocardial lesion attributable to the sickle cell disease is ambiguous through different studies. This article attempts to review the literature about cardiac disease in sickle cell anaemia. |