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Document Details :
Title: Recurrent haemophagocytic syndrome in an HIV-infected patient
Author(s): RAMON I, LIBERT M, GUILLAUME MP, CORAZZA F, KARMALI R
Journal: Acta Clinica Belgica
Volume: 65 Issue: 4 Date: 2010
We describe a case of recurrent haemophagocytic syndrome (HS) in an HIV-infected patient. The first episode was associated with active human herpesvirus 8 infection and progressive Kaposi’s sarcoma which was successfully treated with splenectomy, foscarnet and chemotherapy. The second episode was triggered by a Clostridium difficile colitis and resolved completely after treatment with metronidazole only. Recurrent HS has rarely been described in adult patients out of the setting of relapsing malignancy or autoimmune disease. The chronic immune dysregulation and suppression due to HIV-infection may predispose our patient to development of associated HS. Prognosis of HS remains poor, especially in HIV-infected patients. Rapidly unmasking the causative factor and timely instauration of adequate treatment are critical and may improve outcome.